BETTY J. KINZIE, PHARM.D.; JERRY W. TAYLOR, PHARM.D.
KINZIE BJ, TAYLOR JW. Trimethoprim and Folinic Acid. Ann Intern Med. 1984;101:565. doi: 10.7326/0003-4819-101-4-565_1
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Published: Ann Intern Med. 1984;101(4):565.
To the editor: Trimethoprim-sulfamethoxazole has been used in the United States since 1973 for treatment of infectious diseases. At usual doses of 5 to 8 mg/kg body weight d of trimethoprim, hematologic side effects of this drug combination have been rare. Recently, however, two reports on the use of high-dose trimethoprim-sulfamethoxazole (20 mg/kg d trimethoprim) in patients with the acquired immunodeficiency syndrome and Pneumocystis carinii pneumonia have noted high frequencies of hematologic side effects. Gordin and colleagues (1) and Kovacs and colleagues (2) have reported leukopenia in 13 of 35 patients and 14 of 30 patients, respectively, and thrombocytopenia in
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