PETER STEINHERZ, M.D.
STEINHERZ P.; Vinca Alkaloids and Platelet Function. Ann Intern Med. 1984;101:570. doi: 10.7326/0003-4819-101-4-570-1
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Published: Ann Intern Med. 1984;101(4):570.
To the editor: The recent article by Ahn and associates (1) reported the use of slow infusions of vinca alkaloids in vivo to load autologous platelets for the treatment of idiopathic thrombocytopenic purpura. Although serum vinblastine levels are shown, no data are given for levels achieved in the platelets. Under the conditions described, does the patients' platelet-rich plasma have a higher drug content than platelet-poor plasma? Does the alkaloid concentration achieved effect the function of the platelets?
We have shown a platelet dysfunction in patients treated with vincristine (2). The vinca alkaloid concentrations required for the disruption of microtubules and
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