FREDERICK R. APPELBAUM, M.D.; STEVE DAHLBERG, M.S.; E. DONNALL THOMAS, M.D.; C. DEAN BUCKNER, M.D.; MARTIN A. CHEEVER, M.D.; REGINALD A. CLIFT, F.I.M.L.S.; JOHN CROWLEY, Ph.D.; H. JOACHIM DEEG, M.D.; ALEXANDER FEFER, M.D.; PHILIP D. GREENBERG, M.D.; MARSHALL KADIN, M.D.; WALTER SMITH, M.D.; PATRICIA STEWART, M.D.; KEITH SULLIVAN, M.D.; RAINER STORB, M.D.; PAUL WEIDEN, M.D.
APPELBAUM FR, DAHLBERG S, THOMAS ED, BUCKNER CD, CHEEVER MA, CLIFT RA, et al. Bone Marrow Transplantation or Chemotherapy After Remission Induction for Adults with Acute Nonlymphoblastic Leukemia: A Prospective Comparison. Ann Intern Med. 1984;101:581-588. doi: 10.7326/0003-4819-101-5-581
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Published: Ann Intern Med. 1984;101(5):581-588.
We compared the outcome of marrow transplantation with that of continued chemotherapy for adults with acute nonlymphoblastic leukemia who achieve a first remission. From May 1977 to July 1982, 111 consecutive adults (ages 17 to 50) with newly diagnosed acute nonlymphoblastic leukemia were treated with induction chemotherapy. Ninety patients (81%) had a complete remission. Forty-four remission patients had available donors: 33 received a transplant and 11 did not. Forty-six patients in remission without matched donors were treated with continued chemotherapy. Kaplan-Meier estimates of 5-year, disease-free survival from complete remission are 49% ± 18% for the transplant group and 20% ± 13% for the chemotherapy group. When compared to the chemotherapy group, patients undergoing transplantation had a higher risk of dying during the first 6 months after remission induction but a lower risk of dying thereafter. Within the transplant group, only age influenced survival. Within the chemotherapy group, a leukocyte count of greater than 10 000 mm3 at diagnosis, a French-American-British (FAB) Cooperative Group morphologic status of M-4, M-5, or M-6, and the presence of infection at diagnosis were all associated with shorter survival.
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