JERRY L. PLUSS, D.O.; NICHOLAS J. DiBELLA, M.D.
▸Requests for reprints should be addressed to Jerry L. Pluss, D.O., CPT, MC; Pulmonary Disease Service, Fitzsimons Army Medical Center; Aurora, CO 80045-6000.
PLUSS J., DiBELLA N.; Reversible Central Nervous System Dysfunction Due to Tamoxifen in a Patient with Breast Cancer. Ann Intern Med. 1984;101:652. doi: 10.7326/0003-4819-101-5-652
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Published: Ann Intern Med. 1984;101(5):652.
Tamoxifen is a nonsteroidal antiestrogen currently used primarily in the treatment of patients with hormone-receptor-positive breast cancer (1). Its major advantage over other hormonal agents is its lack of severe side effects. In fact, a recent summary of clinical trials reported that fewer than 3% of 2232 patients had serious side effects that necessitated withdrawal of tamoxifen therapy (2). Central nervous system events are rarely seen and include depression, headache, tremors, confusion, irritability, dizziness, and light-headedness (2-5). One patient has also had encephalopathy with obtundation and pseudobulbar palsy; however, this complication could have resulted from concomitant hypercalcemia (6). We report
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Hematology/Oncology, Breast Cancer.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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