CORWIN Q. EDWARDS, M.D.
Hereditary hemochromatosis is inherited as an autosomal recessive trait linked to the histocompatibility locus on the short arm of chromosome six (1-4). Homozygosity for hemochromatosis among whites is probably common, with an estimated gene frequency of 0.05 to 0.088, corresponding to a heterozygote frequency of 10% to 16% and a disease frequency of 3 to 8 per 1000 population (5-8). Because many persons may have undiagnosed hereditary hemochromatosis, there is need for a simple, inexpensive test to identify young hemochromatosis homozygotes. Because a defective gene product has not been identified, alternates (such as blood tests of iron stores) have to
Learn more about subscription options.
Register Now for a free account.
EDWARDS CQ. Early Detection of Hereditary Hemochromatosis. Ann Intern Med. 1984;101:707-708. doi: 10.7326/0003-4819-101-5-707
Download citation file:
Published: Ann Intern Med. 1984;101(5):707-708.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only