JEROME L. FLEG, M.D.; EDWARD G. LAKATTA, M.D.
To the editors: We read the interesting review by Mulrow and associates (1) and wish to clarify a few points, particularly with regard to our own study (2). Although we did not explicitly state so, our double-blind, placebo-controlled study of digitalis in patients with stable congestive heart failure was in fact randomized. Indeed, after designing a placebo-controlled crossover study, it would make little sense not to randomize. Randomization was done by our hospital pharmacy.
We did not use phonocardiography routinely because only one patient had an S3 gallop heard on auscultation. We agree that a sample size calculation
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FLEG JL, LAKATTA EG. Digitalis in Congestive Heart Failure. Ann Intern Med. 1984;101:879-880. doi: 10.7326/0003-4819-101-6-879_2
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Published: Ann Intern Med. 1984;101(6):879-880.
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