STEPHEN E. STRAUS, M.D.; GIOVANNA TOSATO, M.D.; GARY ARMSTRONG, B.S.M.T.; THOMAS LAWLEY, M.D.; OLIVIA T. PREBLE, Ph.D.; WERNER HENLE, M.D.; RICHARD DAVEY, M.D.; GARY PEARSON, Ph.D.; JAY EPSTEIN, M.D.; IRENA BRUS, M.D.; R. MICHAEL BLAESE, M.D.
STRAUS SE, TOSATO G, ARMSTRONG G, LAWLEY T, PREBLE OT, HENLE W, et al. Persisting Illness and Fatigue in Adults with Evidence of Epstein-Barr Virus Infection. Ann Intern Med. 1985;102:7-16. doi: 10.7326/0003-4819-102-1-7
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Published: Ann Intern Med. 1985;102(1):7-16.
Clinical, serologic, virologic, and immunologic evaluations for 31 adults with chronic illness and fatigue suggested that 23 had persisting Epstein-Barr virus infection. Among these 23 patients, cellular immune mechanisms were generally normal, but 4 had mild immunoglobulin deficiencies. However, 20 patients had abnormal serologic profiles specific for Epstein-Barr virus shown by significantly elevated titers of antibodies to the viral capsid antigen or early antigen, or by a deficiency of late-appearing antibodies. In 11 of 15 patients tested, circulating immune complexes were found. Circulating interferon was not found in 18 patients tested, but the activity of 2-5 oligoadenylate synthetase, an interferon-induced enzyme, was increased in 5 patients studied. Of 19 patients, 18 had persisting suppressor T-cell activity typically found in patients recovering from acute infectious mononucleosis. We believe that the Epstein-Barr virus may be associated with chronic illness in adults.
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