RICHARD M. TIMMS, M.D.; FAREED U. KHAJA, M.D.; GEORGE W. WILLIAMS, Ph.D.
TIMMS RM, KHAJA FU, WILLIAMS GW. Hemodynamic Response to Oxygen Therapy in Chronic Obstructive Pulmonary Disease. Ann Intern Med. 1985;102:29-36. doi: 10.7326/0003-4819-102-1-29
Download citation file:
Published: Ann Intern Med. 1985;102(1):29-36.
At six centers, 203 patients with stabilized hypoxemic chronic obstructive pulmonary disease were evaluated hemodynamically during a continuous or 12-hour oxygen therapy program. Neither oxygen therapy program resulted in correction or near-correction of the baseline hemodynamic abnormalities. The continuous oxygen therapy group did show improvement in pulmonary vascular resistance, pulmonary artery pressure, and stroke volume index. The improvement in pulmonary vascular resistance was associated with improved cardiac function, as evidenced by an increase in baseline and exercise stroke volume index. The nocturnal oxygen therapy group showed stable hemodynamic variables. For both groups, changes in mean pulmonary artery pressure during the first 6 months were associated with subsequent survival after adjustment for association with the baseline mean pulmonary artery pressure. Continuous oxygen therapy can improve the hemodynamic abnormalities of patients with hypoxic chronic obstructive pulmonary disease. The hemodynamic response to this treatment is predictive of survival.
Learn more about subscription options.
Register Now for a free account.
Chronic Obstructive Airway Disease, Pulmonary/Critical Care.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only