JAMES D. DICK, Ph.D.; BRUCE R. ROSENGARD, B.S.; WILLIAM G. MERZ, Ph.D.; ROBERT K. STUART, M.D.; GROVER M. HUTCHINS, M.D.; REIN SARAL, M.D.
DICK JD, ROSENGARD BR, MERZ WG, STUART RK, HUTCHINS GM, SARAL R. Fatal Disseminated Candidiasis Due to Amphotericin-B-Resistant Candida guilliermondii. Ann Intern Med. 1985;102:67-68. doi: 10.7326/0003-4819-102-1-67
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Published: Ann Intern Med. 1985;102(1):67-68.
Disseminated candidiasis is a significant cause of morbidity and mortality in immunocompromised patients. Candida albicans is the commonest pathogen associated with systemic candidiasis, although other species do cause infections (1). Amphotericin B is the drug of choice for treatment of disseminated candidal infection, and the development of amphotericin B resistance is considered rare. We report the case of a patient with aplastic anemia who died from disseminated infection caused by a strain of C. guilliermondii that developed progressive resistance to amphotericin B.
A 52-year-old white woman was admitted to The Johns Hopkins Oncology Center for evaluation and treatment of aplastic
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