MARC FERRIERE, M.D.; HENRI LACHKAR, M.D.; JEAN-LOUIS RICHARD, M.D.; JACQUES BRINGER, M.D.; ANDRE ORSETTI, M.D., Ph.D.; JACQUES MIROUZE, M.D.
FERRIERE M, LACHKAR H, RICHARD J, BRINGER J, ORSETTI A, MIROUZE J. Captopril and Insulin Sensitivity. Ann Intern Med. 1985;102:134-135. doi: 10.7326/0003-4819-102-1-134_3
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Published: Ann Intern Med. 1985;102(1):134-135.
To the editor: Captopril, an oral angiotensin converting enzyme inhibitor, is widely used in the treatment of patients with hypertension and chronic congestive heart failure, and to date no effect of this drug on carbohydrate metabolism has been reported.
We have recently seen three cases of unexplained hypoglycemia in insulin-dependent diabetic patients when captopril was used with their usual insulin dosage. Moreover, in a non-obese, non-insulin-dependent diabetic patient, hypoglycemia necessitated the withdrawal of hypoglycemic oral agents. To study a possible role of captopril on insulin sensitivity, we used the euglycemic glucose-clamp technique (1) in patients before and during treatment with
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