NARASIMHA SURAPANENI, M.D.; RUKMANI RAGHUNATHAN, M.D.; GILDON N. BEALL, M.D.; KATHERINE DANIEL, R.N., M.N.; THOMAS M. MUNDY, M.D.
SURAPANENI N, RAGHUNATHAN R, BEALL GN, DANIEL K, MUNDY TM. Levamisole, Immunostimulation, and the Acquired Immunodeficiency Syndrome. Ann Intern Med. 1985;102:137. doi: 10.7326/0003-4819-102-1-137_1
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Published: Ann Intern Med. 1985;102(1):137.
To the editor: In addition to its antihelminthic and antianergic properties, levamisole is known to normalize the function of T lymphocytes in immunosuppressed patients without affecting B cells (1). We attempted to evaluate these properties in patients with the acquired immunodeficiency syndrome. Levamisole and other immunostimulants have been proposed as treatment for this syndrome but we are unaware of any clinical trials of levamisole.
The five patients who participated in this study were homosexual men with the syndrome (ages, 29 to 37 years) who had recovered from Pneumocystis carinii pneumonia. All five patients had other opportunistic infections such as oral
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