DAVID M. MINTZER, M.D.; FRANCISCO X. REAL, M.D.; LOUISE JOVINO, B.A.; SUSAN E. KROWN, M.D.
Kaposi's sarcoma occurs in about one third of patients with the acquired immunodeficiency syndrome. Although in some patients the tumor is principally a cosmetic problem, other patients have progressive disease with significant morbidity. Twenty-three patients with Kaposi's sarcoma related to the acquired immunodeficiency syndrome were treated with vincristine. Three patients had a coexisting immune thrombocytopenia. Of the 18 patients evaluable for response, 11 had a partial response and 7 had a minor response. The median duration of partial response was 4 + months. All 3 thrombocytopenic patients developed a significant increase in platelet count, which in 2 was sustained with continued treatment for 6 and 9 months, respectively. We conclude that vincristine has antitumor activity in the epidemic form of Kaposi's sarcoma and that it is also effective in the treatment of associated immune thrombocytopenia.
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MINTZER DM, REAL FX, JOVINO L, KROWN SE. Treatment of Kaposi's Sarcoma and Thrombocytopenia with Vincristine in Patients with the Acquired Immunodeficiency Syndrome. Ann Intern Med. 1985;102:200-202. doi: 10.7326/0003-4819-102-2-200
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Published: Ann Intern Med. 1985;102(2):200-202.
Hematology/Oncology, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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