STEPHEN HALL, M.B.B.S.; JOHN L. McCORMICK Jr., M.D.; PHILIP R. GREIPP, M.D.; CLEMENT J. MICHET Jr., M.D.; CHARLES H. McKENNA, M.D.
Fourteen patients with systemic lupus erythematosus had splenectomies done between 1960 and 1982 for treatment of severe thrombocytopenia. Thrombocytopenia persisted or recurred within 1 month postoperatively in five patients and within 6 months in three others. Three patients had late recurrence (18, 30, and 54 months after splenectomy); in two it was probably related to withdrawal of immunosuppressive agents or corticosteroids. Median lowest platelet count before splenectomy and median platelet count at relapse or failure of splenectomy were both 8000/μL. Only two patients maintained normal platelet counts without need for corticosteroids or other treatment. These results differ from those in patients with idiopathic thrombocytopenic purpura. Other treatments should be tried before splenectomy is done for thrombocytopenia in patients with systemic lupus erythematosus.
Learn more about subscription options.
Register Now for a free account.
HALL S, McCORMICK JL, GREIPP PR, MICHET CJ, McKENNA CH. Splenectomy Does Not Cure the Thrombocytopenia of Systemic Lupus Erythematosus. Ann Intern Med. 1985;102:325–328. doi: 10.7326/0003-4819-102-3-325
Download citation file:
Published: Ann Intern Med. 1985;102(3):325-328.
Hematology/Oncology, Lupus Erythematosus, Platelet Disorders, Rheumatology.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only