N. STANLEY NAHMAN, M.D.; MICHAEL R. MURNANE, M.D.; WILLIAM D. KUEHL, M.D.; LEE A. HEBERT, M.D.; JOHN C. NEFF, M.D.; WILLIAM H. BAY, M.D.
NAHMAN NS, MURNANE MR, KUEHL WD, HEBERT LA, NEFF JC, BAY WH. Light-Chain Proteinuria: Spurious False-Negative Reaction to Sulfosalicylic Acid. Ann Intern Med. 1985;102:557-558. doi: 10.7326/0003-4819-102-4-557_2
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Published: Ann Intern Med. 1985;102(4):557-558.
To the editor: We report the case of a patient with multiple myeloma and renal failure secondary to heavy urinary excretion of kappa light chains. This diagnosis was missed initially because the screening test for urinary light chains using sulfosalicylic acid was negative. However, we later discovered that the reaction of the patient's urine to sulfosalicylic acid was positive, but greatly delayed. Thus, the test for urinary light chains by sulfosalicylic acid we originally regarded as being a false-negative test provided, in reality, a spurious false-negative result.
A 73-year-old man was referred to The Ohio State University Hospitals because of
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