JUNIUS J. GONZALES, B.A.; MINDY S. BOHRER, B.A.; JONATHAN T. EDELSON, B.A.; A. MARK FENDRICK, B.A.; MARY F. MORRISON, B.S.
GONZALES J., BOHRER M., EDELSON J., FENDRICK A., MORRISON M.; Proteinuria and Oral Gold Treatment. Ann Intern Med. 1985;102:561-562. doi: 10.7326/0003-4819-102-4-561
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Published: Ann Intern Med. 1985;102(4):561-562.
To the editor: Katz and colleagues (1) have compiled an important and extensive review of proteinuria in patients with rheumatoid arthritis who are receiving oral gold treatments. We want to comment on two problems with this retrospective study and its conclusions.
First, an analysis of potentially confounding disease variables in the study groups is needed to assess the actual contribution of gold treatment to proteinuria independent of other factors. The authors themselves cite the increased risk of proteinuria in patients with other nonrheumatologic disorders (such as diabetes mellitus, urinary tract infections, or congestive heart failure). Also, because at least two
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