DAVID Y. GRAHAM, M.D.; KEMAL AKDAMAR, M.D.; WALTER P. DYCK, M.D.; EDWIN ENGLERT Jr., M.D.; ROBERT G. STRICKLAND, M.D.; JAMES L. ACHORD, M.D.; ALPHONSO A. BELSITO, M.D.; Z. RENO VLAHCEVIC, M.D.; ROBERT N. KORNFIELD, M.D.; WILLIAM B. LONG, M.D.; STEPHEN SONTAG, M.D.; NAURANG M. AGRAWAL, M.D.
Recently the Food and Drug Administration approved cimetidine for the treatment of benign gastric ulcer. Approval was based in part on the results of our large multicenter trial involving 172 patients with benign gastric ulcer between 0.5 and 2.5 cm in diameter: 87 were randomly assigned to receive cimetidine (300 mg four times daily) and 85 to receive placebo. Cimetidine treatment resulted in significantly more rapid healing than placebo; after 2 and 6 weeks of therapy, 10.0% and 44.8% of patients receiving placebo were healed, as compared to 22.6% and 65.1% receiving cimetidine. The results of our study were compared with the time-response curve previously published (0, 4, and 8 weeks of therapy). The combined data yielded linear healing rates for the first 8 weeks of therapy (r > 0.99 for both cimetidine and placebo). These studies can be used to define expectations for healing of benign gastric ulcer, and we recommend follow-up intervals of 8 and, if unhealed, 16 weeks.
Learn more about subscription options.
Register Now for a free account.
GRAHAM DY, AKDAMAR K, DYCK WP, ENGLERT E, STRICKLAND RG, ACHORD JL, et al. Healing of Benign Gastric Ulcer: Comparison of Cimetidine and Placebo in the United States. Ann Intern Med. 1985;102:573–576. doi: 10.7326/0003-4819-102-5-573
Download citation file:
Published: Ann Intern Med. 1985;102(5):573-576.
Gastroenterology/Hepatology, Peptic Disease, Peptic Ulcer.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only