JANET K. A. NICHOLSON, Ph.D.; J. STEVEN McDOUGAL, M.D.; HAROLD W. JAFFE, M.D.; THOMAS J. SPIRA, M.D.; M. SUSAN KENNEDY, B.S.; BONNIE M. JONES, B.S.; WILLIAM W. DARROW, Ph.D.; MEADE MORGAN, Ph.D.; MARJORIE HUBBARD, M.S.
Immunologic and serologic studies were done in 120 homosexual men who reportedly had no symptoms related to the acquired immunodeficiency syndrome. Forty-nine men (41%) had antibody to the retrovirus human T-lymphotropic virus type lll/lymphadenopathy-associated virus (HTLV-III/LAV), and 37 (31%) had an abnormal T-cell subset ratio and other immunologic abnormalities. These abnormalities were almost exclusively confined to men seropositive for the retrovirus. Multivariate statistical analysis showed that exposure to HTLV-III/LAV was the single best predictor of T-cell (and other) immunologic abnormalities. Sexual practice, particularly receptive anal intercourse, predicted exposure to HTLV-III/LAV but was not independently related to T-cell abnormalities. The association of other microbial serologic findings with HTLV-III/LAV seropositivity or T-cell changes was a coincidental function of sexual activity. Immunologic abnormalities in asymptomatic homosexual men are mostly related to exposure to HTLV-III/LAV.
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NICHOLSON JKA, McDOUGAL JS, JAFFE HW, SPIRA TJ, KENNEDY MS, JONES BM, et al. Exposure to Human T-Lymphotropic Virus Type III/Lymphadenopathy-Associated Virus and Immunologic Abnormalities in Asymptomatic Homosexual Men. Ann Intern Med. 1985;103:37–42. doi: 10.7326/0003-4819-103-1-37
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Published: Ann Intern Med. 1985;103(1):37-42.
HIV, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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