DAVID A. PEURA, M.D.; LAWRENCE F. JOHNSON, M.D.
The efficacy of Cimetidine in the prevention and treatment of stress-induced gastroduodenal lesions was evaluated in a randomized, double-blind, placebo-controlled study in which serial endoscopy was used to examine patients without clinical evidence of bleeding who were admitted to a medical intensive care unit. Endoscopy showed that 14 of 21 patients treated with Cimetidine, compared with 5 of 18 patients treated with placebo, had normal or improved gastroduodenal mucosa (p < 0.05). Endoscopic signs of bleeding cleared or did not develop in 20 patients treated with Cimetidine and in 11 patients treated with placebo (p < 0.01). Significantly fewer blood transfusions were given to patients with endoscopic signs of bleeding in the cimetidine-treated group (0.5 ±0.3 [SE] units) than in placebo-treated patients (4.5 ±1.5 units; p < 0.05). The mortality rate was not statistically different between treatment groups. By preventing established gastroduodenal stress lesions from progressing in severity, Cimetidine diminished both bleeding and the need for transfusions.
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PEURA DA, JOHNSON LF. Cimetidine for Prevention and Treatment of Gastroduodenal Mucosal Lesions in Patients in an Intensive Care Unit. Ann Intern Med. 1985;103:173–177. doi: 10.7326/0003-4819-103-2-173
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Published: Ann Intern Med. 1985;103(2):173-177.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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