M. MICHAEL WOLFE, M.D.; DEVENDRA K. JAIN, Ph.D.; JAMES R. EDGERTON, M.D.
A 63-year-old man with a 2-year history of upper gastrointestinal ulcers was found to have the Zollinger-Ellison syndrome. Despite histologic verification of gastrinoma, several fasting serum gastrin concentrations were normal. However, in response to intravenous secretin infusion, a paradoxical increase in serum gastrin levels indicative of gastrinoma was seen. Although serum gastrin concentrations in patients with suspected gastrinoma may be persistently normal, provocative testing may be necessary to establish the diagnosis of the Zollinger-Ellison syndrome.
Learn more about subscription options.
Register Now for a free account.
WOLFE MM, JAIN DK, EDGERTON JR. Zollinger-Ellison Syndrome Associated with Persistently Normal Fasting Serum Gastrin Concentrations. Ann Intern Med. 1985;103:215-217. doi: 10.7326/0003-4819-103-2-215
Download citation file:
Published: Ann Intern Med. 1985;103(2):215-217.
Endocrine and Metabolism, Endocrine Cancer, Gastroenterology/Hepatology, Hematology/Oncology, Peptic Disease.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only