HAROLD BURGER, Ph.D.; BARBARA WEISER, M.D.; WILLIAM S. ROBINSON, M.D.; JEFFREY LIFSON, M.D.; EDGAR ENGLEMAN, M.D.; CHRISTINE ROUZIOUX, Ph.D.; FRANÇOISE BRUN-VÉZINET, M.D.; FRANÇOISE BARRÉ-SINOUSSI, Ph.D.; LUC MONTAGNIER, M.D.; JEAN-CLAUDE CHERMANN, Ph.D.
We present evidence of transmission of lymphadenopathy-associated virus (LAV)/human T-lymphotropic virus type III (HTLV-III) from a man to his wife, and a return to a normal number of T-helper lymphocytes and loss of antibody after discontinuing sexual exposure to LAV/HTLV-III. The man had hemophilia A, and developed the lymphadenopathy syndrome, antibody to LAV, and a low number of T-helper lymphocytes. His wife, who had no risks for the acquired immunodeficiency syndrome other than sexual contact with him, developed LAV antibody (titer, 1:160) and a mildly decreased number of T-helper cells. The husband subsequently developed the syndrome and lost the LAV antibody. During 10 months of follow-up his wife remained clinically well, discontinued exposure to semen, and then lost the LAV antibody, and regained a normal number of T-helper cells.
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BURGER H, WEISER B, ROBINSON WS, LIFSON J, ENGLEMAN E, ROUZIOUX C, et al. Transient Antibody to Lymphadenopathy-Associated Virus/Human T-Lymphotropic Virus Type III and T-Lymphocyte Abnormalities in the Wife of a Man Who Developed the Acquired Immunodeficiency Syndrome. Ann Intern Med. 1985;103:545–547. doi: 10.7326/0003-4819-103-4-545
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Published: Ann Intern Med. 1985;103(4):545-547.
HIV, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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