PHILIP L. SMITH, M.D.; AVRAM R. GOLD, M.D.; DEBORAH A. MEYERS, Ph.D.; EDWARD F. HAPONIK, M.D.; EUGENE R. BLEECKER, M.D.
SMITH PL, GOLD AR, MEYERS DA, HAPONIK EF, BLEECKER ER. Weight Loss in Mildly to Moderately Obese Patients with Obstructive Sleep Apnea. Ann Intern Med. 1985;103:850-855. doi: 10.7326/0003-4819-103-6-850
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Published: Ann Intern Med. 1985;103(6_Part_1):850-855.
The therapeutic effects of weight loss were evaluated in 15 hypersomnolent patients with moderately severe obstructive sleep apnea. As patients decreased their body weight from 106.2 ± 7.3 kg (mean ± SE) to 96.6 ± 5.9 kg, apnea frequency fell from 55.0 ± 7.5 to 29.2 ± 7.1 episodes/h (p < 0.01) in non-rapid-eye-movement sleep with an associated significant decline in the mean oxyhemoglobin saturation during the remaining episodes of sleep apnea from 11.9 ± 2.4% to 7.9 ± 1.9% (p < 0.02). Sleep patterns also improved, with a reduction in stage I sleep from 40.2 ± 7.3% to 23.5 ± 4.8% (p < 0.01), and a rise in stage II sleep from 37.3 ± 7.0% to 49.4 ± 4.6% (p < 0.03). In the 9 patients with the most marked fall in apnea frequency, the tendency toward daytime hypersomnolence was decreased (p < 0.05). No significant changes in sleep patterns occurred in 8 age- and weight-matched control patients who did not lose weight. Moderate weight loss alone can alleviate sleep apnea, improve sleep architecture, and decrease daytime hypersomnolence.
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Pulmonary/Critical Care, Obesity, Sleep Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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