ANTHONY KULCZYCKI, M.D.
KULCZYCKI A. Aspartame-lnduced Urticaria. Ann Intern Med. 1986;104:207-208. doi: 10.7326/0003-4819-104-2-207
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Published: Ann Intern Med. 1986;104(2):207-208.
Aspartame (NutraSweet; G.D. Searle & Co., Skokie, Illinois), the dipeptide composed of aspartic acid and the methyl ester of phenylalanine, is a low-calorie artificial sweetener 180 times sweeter than sucrose (1, 2). Although questions have been raised about its safety (3-5), the Food and Drug Administration (FDA) approved aspartame for use in carbonated beverages in 1983, and currently it is used extensively in diet soft drinks, chewing gums, cereals, desserts, and sugar substitutes. One case of granulomatous panniculitis resulting from aspartame has been documented (6). This report describes a case of aspartame-induced urticaria confirmed by doubleblind challenge.
A 23-year-old white
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