ABIGAIL ZUGER, M.D.; EDDIE LOUIE, M.D.; ROBERT S. HOLZMAN, M.D.; MICHAEL S. SIMBERKOFF, M.D.; JAMES J. RAHAL, M.D.
Between 1 January 1981 and 1 December 1984, 34 of 396 patients with the acquired immunodeficiency syndrome (AIDS) developed cryptococcal infections. Twenty-six cases are reviewed. Twenty-two patients had brain or meningeal disease; the others had pulmonary disease (2 patients), pericarditis (1 patient), and antigenemia (1 patient). During treatment, 3 patients died of cryptococcosis and 3 died of other causes. Fifteen patients were followed for more than 6 weeks after treatment. Of 8 patients who received no additional amphotericin B, 4 had relapses and died of cryptococcosis within 6 months, 3 died of other causes, and 1 survived. Of 7 patients who received maintenance therapy with amphotericin B, none had relapses, 3 died of other causes, and 4 survived. Our data suggest that maintenance therapy with amphotericin may be needed to prevent relapse in patients with AIDS.
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ZUGER A, LOUIE E, HOLZMAN RS, SIMBERKOFF MS, RAHAL JJ. Cryptococcal Disease in Patients with the Acquired Immunodeficiency Syndrome: Diagnostic Features and Outcome of Treatment. Ann Intern Med. 1986;104:234-240. doi: 10.7326/0003-4819-104-2-234
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Published: Ann Intern Med. 1986;104(2):234-240.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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