MARCIA J. BROWNE, M.D.; SUSAN M. HUBBARD, R.N.; DAN L. LONGO, M.D.; RICHARD FISHER, M.D.; ROBERT WESLEY, Ph.D.; DANIEL C. IHDE, M.D.; ROBERT C. YOUNG, M.D.; PHILIP A. PIZZO, M.D.
▸Requests for reprints should be addressed to Philip A. Pizzo, M.D.; Pediatric Branch, National Cancer Institute, Building 10, Room 13N240; Bethesda, MD 20892.
BROWNE MJ, HUBBARD SM, LONGO DL, FISHER R, WESLEY R, IHDE DC, et al. Excess Prevalence of Pneumocystis carinii Pneumonia in Patients Treated for Lymphoma with Combination Chemotherapy. Ann Intern Med. 1986;104:338-344. doi: 10.7326/0003-4819-104-3-338
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Published: Ann Intern Med. 1986;104(3):338-344.
A significantly greater prevalence of interstitial pulmonary infiltrates and Pneumocystis carinii pneumonitis occurred on one arm of a randomized study comparing ProMACE-CytaBOM (prednisone, methotrexate with leucovorin, doxorubicin, cyclophosphamide, etoposide; cytarabine, bleomycin, vincristine, methotrexate with leucovorin) to ProMACE-MOPP (ProMACE, mechlorethamine, vincristine, prednisone, procarbazine) chemotherapy in patients with lymphoma. Of the 37 patients receiving ProMACE-CytaBOM, 13 (35.1%) developed an interstitial pulmonary infiltrate compared with 3 of 32 (9.4%) patients receiving ProMACE-MOPP (p2 = 0.02). Of the 13 patients receiving ProMACE-CytaBOM who had infiltrates, open lung biopsy in 7 showed P. carinii; 5 others had clinically suspected P. carinii pneumonia, and 1 had blastomycosis. No patient receiving ProMACE-MOPP had documented or suspected P. carinii pneumonia. Of patients with infiltrates, 3 of 13 on ProMACE-CytaBOM but 0 of 3 on ProMACE-MOPP died. Two other patients on ProMACE-CytaBOM who had P. carinii pneumonia died. Groups did not differ in predisposing risk factors or patient history. The exact cause for the increased prevalence of P. carinii infection in patients receiving ProMACE-CytaBOM was not ascertained. These data emphasize that new drug regimens may lead to unanticipated complications.
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Hematology/Oncology, Infectious Disease, Pulmonary/Critical Care, Leukemia/Lymphoma, Pneumonia.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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