G. FOREST QUIMBY, B.A.; CANAN AVUNDUK BONNICE, M.D., Ph.D.; SUMNER H. BURSTEIN, Ph.D.; GREGORY L. EASTWOOD, M.D.
QUIMBY GF, BONNICE CA, BURSTEIN SH, EASTWOOD GL. Active Smoking Depresses Prostaglandin Synthesis in Human Gastric Mucosa. Ann Intern Med. 1986;104:616-619. doi: 10.7326/0003-4819-104-5-616
Download citation file:
Published: Ann Intern Med. 1986;104(5):616-619.
To determine the effect of smoking on gastroduodenal mucosal prostaglandin synthesis, endoscopies were done after an overnight fast on 10 nonsmokers, 12 active smokers who smoked four cigarettes in the hour before endoscopy, and then 11 of the smokers who refrained from smoking for 12 hours. Biopsy samples of fundic, antral, and duodenal mucosae were incubated, and the accumulation of prostaglandin E2 and 6-keto-prostaglandin F1α in the incubation medium was measured by radioimmunoassay. We assumed that accumulation of prostaglandins in the medium reflected mucosal synthesis. Comparison of active and inactive smoking showed that active smoking significantly depressed 6-keto-prostaglandin F1α synthesis in antral and fundic mucosa and prostaglandin E2 synthesis in antral mucosa. Comparison of nonsmokers and inactive smokers showed no difference in prostaglandin synthesis. Active smoking causes a transient decrease in prostaglandin synthesis in fundic and antral mucosae. This depression of prostaglandin synthesis may help explain slower ulcer healing and predisposition to ulcer recurrence in smokers.
Learn more about subscription options.
Register Now for a free account.
Cardiology, Gastroenterology/Hepatology, Tobacco, Alcohol, and Other Substance Abuse, Coronary Risk Factors, Smoking.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only