BOUE FRANÇOIS, M.D.; BENOIT COFFIN, M.D.; JEAN-FRANÇOIS DELFRAISSY, M.D.
FRANÇOIS B, COFFIN B, DELFRAISSY J. Danazol and Cholestatic Hepatitis. Ann Intern Med. 1986;105:139-140. doi: 10.7326/0003-4819-105-1-139_3
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Published: Ann Intern Med. 1986;105(1):139-140.
To the editor: Danazol, used since 1971 for treatment of pelvic endometriosis, cystic disease of the breast, and hereditary angioneurotic edema, has recently been reported to be effective in idiopathic thrombocytopenic purpura (1). Because danazol is a C17 alkylated anabolic steroid, hepatic dysfunction and jaundice might be expected. We report a case of cholestatic hepatitis apparently induced by danazol.
A 73-year-old woman was referred with idiopathic thrombocytopenic purpura responding to prednisone. Treatment was stopped 6 months later with a good result. A moderate relapse occurred 1 year afterwards, and prednisone therapy was restarted. Because of iatrogenic Cushing's syndrome, prednisone was
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