M. NOPPEN, M.D.; W. SCHANDEVIJL, M.D.; W. MUSCH; W. VlNCKEN
To the editor: Although the exact pathogenetic mechanism of hypercalcemia in sarcoidosis remains unknown, several studies (1-3) have suggested that the basic disturbance is an increase in circulating levels of 1,25-dihydroxyvitamin D. Increased levels of this substance are thought to be due to excessive synthesis, reflecting aberrant 1-alpha-hydroxylase activity (3). Sarcoid tissue may be the locus of this ectopic 1-alpha-hydroxylase activity (4). We present a clinical observation supporting the involvement of sarcoid tissue.
A 47-year-old woman was hospitalized in May 1982 for persistent cough and wheezing due to extrinsic asthma. Chest roentgenograms showed an enlargement of the superior mediastinum, and
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NOPPEN M, SCHANDEVIJL W, MUSCH W, VlNCKEN W. Sarcoidosis and Hypercalcemia. Ann Intern Med. 1986;105:143-144. doi: 10.7326/0003-4819-105-1-143_3
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Published: Ann Intern Med. 1986;105(1):143-144.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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