YVES LAURIAN, M.D.; PHILIPPE LE BRAS, M.D.; AXEL ELLRODT, M.D.; PATRICK ALVIN, M.D.
LAURIAN Y, LE BRAS P, ELLRODT A, ALVIN P. Immune Thrombocytopenia Gammaglobulin, and Seropositivity to the Human T-Lymphotropic Virus Type III. Ann Intern Med. 1986;105:145-146. doi: 10.7326/0003-4819-105-1-145_3
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Published: Ann Intern Med. 1986;105(1):145-146.
To the editior: Walsh and colleagues (1) and Abrams and colleagues (2) recently described the successful treatment of immune thrombocytopenia with steroids or splenectomy in patients with antibodies to the lymphadenopathy-associated virus/human T-lymphotropic virus type III (LAV/HTLV III).
We report our experience with intravenous gammaglobulin in such patients.
Immune thrombocytopenia occurred in 17 patients (12 hemophiliacs, 4 intravenous drug users, 1 homosexual man) out of 248 LAV/HTLV-III-seropositive patients seen in our hospital since 1981. The presence of these antibodies was assessed by an enzyme-linked immunosorbent assay (ELA-VIA; Diagnostics Pasteur, France) and was confirmed by Western blot analysis. Thrombocytopenia was severe
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