GREG SIMON, M.D.
SIMON G. Efficacy of Pneumococcal Vaccine. Ann Intern Med. 1986;105:147-148. doi: 10.7326/0003-4819-105-1-147
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Published: Ann Intern Med. 1986;105(1):147-148.
To the editor: In your January issue, Bolan and coworkers (1) argue for the efficacy of pneumococcal vaccine, continuing work first reported 4 years ago (2). They describe current difficulties in mounting a prospective randomized trial and present an analysis of available data on serotype prevalence in vaccinated and unvaccinated populations. Their report does not include the full description of methods found in the original paper (2).
Briefly restated, those methods state that in a vaccinated population (size N1), let a equal cases of pneumococcal disease caused by serotypes included in the vaccine, and let b equal cases due to
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