DAVID M. SKILLRUD, M.D.; KENNETH P. OFFORD, M.S.; R. DREW MILLER, M.D.
SKILLRUD DM, OFFORD KP, MILLER RD. Higher Risk of Lung Cancer in Chronic Obstructive Pulmonary Disease: A Prospective, Matched, Controlled Study. Ann Intern Med. 1986;105:503-507. doi: 10.7326/0003-4819-105-4-503
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Published: Ann Intern Med. 1986;105(4):503-507.
To assess the risk of lung cancer in patients with chronic obstructive pulmonary disease, we matched, on the basis of age, sex, occupation, and smoking history, 113 persons ("cases") who had a forced expiratory volume in 1 second (FEV1) of 70% or less of predicted normal with 113 control persons who had an FEV1 of 85% or more. All persons were observed from 1973-74 through 1984 for a diagnosis of lung cancer, death from lung cancer, and death from any cause. At entry, subjects had an age range of 45 to 59 years; men numbered 186 and women 40. Histologically proven lung cancer developed in 9 cases and in 2 controls, all men. The rate of development of lung cancer was significantly different in the two groups (p = 0.024): the 10-year cumulative percentage was 8. 8% for cases and 2.0% for controls. Overall 10-year survival was estimated to be 74.0% for cases and 91.1% for controls (p < 0.001).
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Chronic Obstructive Airway Disease, Hematology/Oncology, Lung Cancer, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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