JULIAN E. DONCKIER, M.D.; HENOCH T. MEUNIER, M.D.; JEAN-MARIE KETELSLEGERS, M.D.; ANDRÉ E. LAMBERT, M.D.
DONCKIER JE, MEUNIER HT, KETELSLEGERS J, LAMBERT AE. Atrial Natriuretic Peptide and the Syndrome of Inappropriate Secretion of Antidiuretic Hormone. Ann Intern Med. 1986;105:795-796. doi: 10.7326/0003-4819-105-5-795_2
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Published: Ann Intern Med. 1986;105(5):795-796.
To the editor: Atrial natriuretic peptide, a 28-amino-acid peptide with potent natriuretic and diuretic activity, has been isolated from atrial muscle cells (1). Its release occurs in response to volume loading in normal persons (2) and in patients with some conditions such as heart and renal failure (3, 4). We report elevated levels of this peptide in a patient with a syndrome of inappropriate secretion of antidiuretic hormone (SIADH), another condition associated with fluid overload.
A 75-year-old woman with known Waldenström's macroglobulinemia was admitted for increasing drowsiness, fever, and hyponatremia. Clinical examination revealed a normal skin turgor and distended veins
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