URIEL S. BARZEL, M.D.
BARZEL US. Resistance to Calcitriol Therapy in Postsurgical Hypoparathyroidism. Ann Intern Med. 1986;105:970-971. doi: 10.7326/0003-4819-105-6-970
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Published: Ann Intern Med. 1986;105(6):970-971.
To the editor: In their brief report, Graber and Schulman (1) describe the case of a man with postoperative hypoparathyroidism in whom large doses of calcitriol (1,25-dihydroxyvitamin D), dihydrotachysterol, and hydrochlorothiazide failed to return serum calcium levels to normal until the correction of hypomagnesemia (which also developed in the immediate post-operative period). Their report calls attention to the importance of a normal blood magnesium level for the management of post-surgical hypoparathyroidism. Of note, however, even before the development of the hypomagnesemia, their patient failed to respond to calcitriol (0.25 to 0.50 µg/d), to dihydrotachysterol (0.25 mg every 6
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