MARK I. TARAGIN, M.D.
To the editor: Doyle and coworkers (1) discuss adjusted subcutaneous heparin compared with continuous intravenous heparin in patients with acute deep vein thrombosis. There are many interesting observations, especially about the subject of silent pulmonary embolism, but I have grave reservations about their conclusions.
In a study that attempts to show no difference between two alternatives, a power analysis, to show the ability of the study to detect a difference if it exists, is crucial. Indeed, Freiman and associates (2) showed this deficiency in the literature. If one calculates an odds ratio with a 95% confidence interval, one finds that
Learn more about subscription options.
Register Now for a free account.
TARAGIN MI. Alternate Methods of Heparin Administration. Ann Intern Med. 1988;108:306-307. doi: 10.7326/0003-4819-108-2-306
Download citation file:
Published: Ann Intern Med. 1988;108(2):306-307.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only