PETER L. FROMMER, M.D.; JOEL VERTER, Ph.D.; JANET WITTERS, Ph.D.; WILLIAM CASTELLI, M.D.
To the editor: Taylor and associates (1) use data from the Framingham Heart Study in an attempt to predict the impact of lowering blood cholesterol on life expectancy. They have created a mathematical model we believe is conceptually flawed. The coefficients used estimate 2-year, not long-term, risk. Their approach models temporal trajectories of cholesterol and other risk factors from which they create longitudinal survival data and calculate life expectancy. Unfortunately, to predict the life expectancy of a cohort of 20-year-old persons based on 2-year snippets of risk, the authors must create artificial continuities more than 30 times. Furthermore, instead of
Learn more about subscription options.
Register Now for a free account.
FROMMER PL, VERTER J, WITTERS J, CASTELLI W. Cholesterol Reduction and Life Expectancy. Ann Intern Med. 1988;108:313-314. doi: 10.7326/0003-4819-108-2-313
Download citation file:
Published: Ann Intern Med. 1988;108(2):313-314.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only