PETER L. FROMMER, M.D.; JOEL VERTER, Ph.D.; JANET WITTERS, Ph.D.; WILLIAM CASTELLI, M.D.
To the editor: Taylor and associates (1) use data from the Framingham Heart Study in an attempt to predict the impact of lowering blood cholesterol on life expectancy. They have created a mathematical model we believe is conceptually flawed. The coefficients used estimate 2-year, not long-term, risk. Their approach models temporal trajectories of cholesterol and other risk factors from which they create longitudinal survival data and calculate life expectancy. Unfortunately, to predict the life expectancy of a cohort of 20-year-old persons based on 2-year snippets of risk, the authors must create artificial continuities more than 30 times. Furthermore, instead of
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FROMMER PL, VERTER J, WITTERS J, CASTELLI W. Cholesterol Reduction and Life Expectancy. Ann Intern Med. 1988;108:313–314. doi: 10.7326/0003-4819-108-2-313
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Published: Ann Intern Med. 1988;108(2):313-314.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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