WILLIAM R. BYRNE, M.D.; CHARLES P. WAJSZCZUK, M.D.
BYRNE WR, WAJSZCZUK CP. Cryptococcal Meningitis in the Acquired Immunodeficiency Syndrome (AIDS): Successful Treatment with Fluconazole after Failure of Amphotericin B. Ann Intern Med. 1988;108:384-385. doi: 10.7326/0003-4819-108-3-384
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Published: Ann Intern Med. 1988;108(3):384-385.
Cryptococcal meningitis, a common complication of the acquired immunodeficiency syndrome (AIDS), is usually associated with a high mortality (1) and the need for lifelong therapy with amphotericin B (2). Fluconazole is a recently developed triazole compound that acts against Cryptococcus neoformans in vitro, shows efficacy in an animal model of cryptococcal meningitis, and has good penetration into cerebrospinal fluid (3). Fluconazole therapy has been used successfully to treat a patient with AIDS who had a relapse of cryptococcal meningitis (4), when retreatment with amphotericin B and 5-flucytosine was contraindicated because of granulocytopenia. A determination of the relative efficacy of treatment
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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