FRANZ GREMMEL, M.D.; WILFRED DRUML, M.D.; PAUL SCHMIDT, M.D.; WOLFGANG GRANINGER, M.D., PH.D.
GREMMEL F, DRUML W, SCHMIDT P, GRANINGER W. Cyclosporin in Wegener Granulomatosis. Ann Intern Med. 1988;108:491. doi: 10.7326/0003-4819-108-3-491_1
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Published: Ann Intern Med. 1988;108(3):491.
To the editor: The combination of cyclophosphamide and prednisolone is the treatment of choice in Wegener granulomatosis (1). Despite the high remission rate achieved, 7% of the patients (mainly those with rapidly progressive disease) will not respond, and cytotoxic therapy carries a considerable risk, with several patients in remission having died from opportunistic infections (1, 2). We treated two patients who had Wegener granulomatosis (one with multiorgan failure unresponsive to cyyclophosphamide and the other with renal failure) with cyclosporin A. This treatment resulted in a sustained remission and recovery of renal function.
A 45-year-old man was admitted to the intensive
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