WALTER S. JOHNSON, M.D.; DONALD R. MILLER, PHARM.D.
JOHNSON WS, MILLER DR. Ranitidine and Bradycardia. Ann Intern Med. 1988;108:493. doi: 10.7326/0003-4819-108-3-493
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Published: Ann Intern Med. 1988;108(3):493.
To the editor: The histamine-2 (H2) receptor antagonist drugs (Cimetidine, ranitidine, and famotidine) are generally well tolerated. However, several less common but serious side effects have been reported, including mental confusion, gynecomastia, neutropenia, hepatitis, and cardiac arrhythmias. We report the case of a patient who had two episodes of bradycardia possibly related to ranitidine treatment.
A hypertensive, diabetic 73-year-old man with mild renal insufficiency was transferred to our hospital 2 days after emergency surgery for a colonic perforation and subsequent Klebsiella peritonitis, renal failure, and confusion. At admission he was hypovolemic, and intravenous fluid replacement and dopamine were started.
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