P.H.J. FRISSEN, M.D.; A. STRONKHORST, M.D.; J.K.M. EEFTINCK SCHATTENKERK, M.D.; S.A. DANNER, M.D.
To the editor: Pneumocystis carinii pneumonia is the comonest opportunistic infection in the acquired immunodeficiency syndrome (AIDS). Without chemoprophylaxis after initial therapy the relapse rate is up to 80% (1). The use of fansidar (pyrimethamine-sulfadoxine) (Roche Laboratories, Nutley, New Jersey), one tablet a week, is convenient and effective in patients with cotrimoxazole intolerance (2). We report the recurrence of P. carinii pneumonia during chemoprophylaxis with fansidar in two patients.
A 38-year-old homosexual man received a 2-week course of daily high-dose cotrimoxazole (960 mg of trimethoprim and 4800 mg of sulfamethoxazole) for parasitologically proven P. carinii pneumonia with good clinical result.
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FRISSEN P, STRONKHORST A, SCHATTENKERK JE, DANNER S. Fansidar and Pneumocystis carinii Pneumonia. Ann Intern Med. 1988;108:638–639. doi: 10.7326/0003-4819-108-4-638_3
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Published: Ann Intern Med. 1988;108(4):638-639.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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