GAIL P. DALSKY, Ph.D.; KAREN S. STOCKE, B.S.; ALI A. EHSANI, M.D.; EDUARDO SLATOPOLSKY, M.D.; WALDON C. LEE; STANLEY J. BIRGE, M.D.
DALSKY GP, STOCKE KS, EHSANI AA, SLATOPOLSKY E, LEE WC, BIRGE SJ. Weight-Bearing Exercise Training and Lumbar Bone Mineral Content in Postmenopausal Women. Ann Intern Med. 1988;108:824-828. doi: 10.7326/0003-4819-108-6-824
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Published: Ann Intern Med. 1988;108(6):824-828.
Study Objective: To assess the effect of weight-bearing exercise training and subsequent detraining on lumbar bone mineral content in postmenopausal women.
Design: Non-randomized, controlled, short-term (9 months) trial and long-term (22 months) exercise training and detraining (13 months).
Setting: Section of applied physiology at a university school of medicine.
Patients: Thirty-five healthy, sedentary postmenopausal women, 55 to 70 years old. All women completed the study. There was 90% compliance with exercise training.
Interventions: All women were given calcium, 1500 mg daily. The exercise group did weight-bearing exercise (walking, jogging, stair climbing) at 70% to 90% of maximal oxygen uptake capacity for 50 to 60 min, 3 times weekly.
Measurements and Main Results: Bone mineral content increased 5. 2% (95% confidence interval [Cl], 2.0% to 8.4%; P = 0.0037) above baseline after short-term training whereas there was no change (-1.4%) in the control group. After 22 months of exercise, bone mineral content was 6.1% (95% Cl, 3.9% to 8.3% above baseline; P =0.0001) in the long-term training group. After 13 months of decreased activity, bone mass was 1.1% above baseline in the detraining group.
Conclusions: Weight-bearing exercise led to significant increases above baseline in bone mineral content which were maintained with continued training in older, postmenopausal women. With reduced weight-bearing exercise, bone mass reverted to baseline levels. Further studies are needed to determine the threshold exercise prescription that will produce significant increases in bone mass.
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Endocrine and Metabolism, Metabolic Bone Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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