DIETMAR FUCHS, Ph.D.; ARNO HAUSEN, Ph.D.; GILBERT REIBNEGGER, D.Sc.; ERNST R. WERNER, D.Sc.; MANFRED P. DIERICH, M.D.; HELMUT WACHTER, Ph.D.
FUCHS D, HAUSEN A, REIBNEGGER G, WERNER ER, DIERICH MP, WACHTER H. Psoriasis, Gamma-Interferon, and the Acquired Immunodeficiency Syndrome. Ann Intern Med. 1987;106:165. doi: 10.7326/0003-4819-106-1-165_2
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Published: Ann Intern Med. 1987;106(1):165.
To the editor: The association between the acquired immunodeficiency syndrome (AIDS) and seborrheic dermatitis has been described several times. It has also indicated that enhanced interferon levels might serve as an important factor associated with flares of psoriasis. On the one hand, patients treated with alpha-interferon have exacerbation of severe psoriasis (1), and on the other hand, gamma-interferon and enhanced expression of class-II major histocompatibility complex antigens on Langerhans' cells in the epidermis are expected to trigger or exacerbate psoriasis (2). The latter observations are in agreement with data showing successful treatment of severe recalcitrant psoriasis by immunosuppressive protocols (methotrexate
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