MARIA A. VIVIANI, M.D.; ANNA M. TORTORANO, Ph.D.; PAOLO CARBONERA GIANI, M.D.; CLAUDIO ARICI, M.D.; ANTONIO GOGLIO, M.D.; PAOLO CROCCHIOLO, M.D.; MAURO ALMAVIVA, M.D.
VIVIANI MA, TORTORANO AM, GIANI PC, ARICI C, GOGLIO A, CROCCHIOLO P, et al. Itraconazole for Cryptococcal Infection in the Acquired Immunodeficiency Syndrome. Ann Intern Med. 1987;106:166. doi: 10.7326/0003-4819-106-1-166_1
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Published: Ann Intern Med. 1987;106(1):166.
To the editor: Relapses of cryptococcal infection in patients with the acquired immunodeficiency syndrome (AIDS) have been reported frequently, and need of a long-term antifungal therapy is evident (1-3). The new triazole derivative, itraconazole (Janssen Pharmaceutica Beerse, Belgium), seems to be a promising drug for this purpose, as documented by our first results in the treatment of disseminated cryptococcosis in three patients with AIDS (4).
All the patients were at first given the conventional therapy and had marked improvement, but treatment was discontinued after 20 to 45 days because of intolerance or toxicity in two patients and because of the
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