AARON SPITAL, M.D.
To the editor: In their excellent review of ascites in cirrhosis, Drs. Rocco and Ware (1) recommend spironolactone when diuretic therapy is indicated. This widely accepted practice was recently supported by the results of a controlled study comparing the efficacies of spironolactone and furosemide (2). Nonetheless, I have several concerns with this approach.
First, the use of spironolactone for cirrhotic ascites derives from the concept that hyperaldosteronism plays a major role in the sodium retention of cirrhosis. More recent data have cast doubt on this hypothesis, and it now appears likely that aldosterone is not the primary cause of impaired
Learn more about subscription options.
Register Now for a free account.
SPITAL A. Ascites in Cirrhosis. Ann Intern Med. 1987;106:169–170. doi: 10.7326/0003-4819-106-1-169_2
Download citation file:
Published: Ann Intern Med. 1987;106(1):169-170.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only