ALFRED L. GEORGE, M.D.; CHARLES A. WOOD, Pharm.D.
GEORGE AL, WOOD CA. Succinylcholine-Induced Hyperkalemia Complicating the Neuroleptic Malignant Syndrome. Ann Intern Med. 1987;106:172. doi: 10.7326/0003-4819-106-1-172_1
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Published: Ann Intern Med. 1987;106(1):172.
To the editor: Severe hyperkalemia may complicate the use of succinylcholine in patients with major burns, direct muscle trauma, and various neuromuscular disorders (1-3). Nontraumatic rhabdomyolysis is common in the neuroleptic malignant syndrome (4) but has not been recognized as a risk factor for succinylcholine-induced hyperkalemia. We present the case of a patient with the neuroleptic malignant syndrome complicated by massive rhabdomyolysis in whom life-threatening hyperkalemia developed after the administration of intravenous succinylcholine.
A 28-year-old white man was admitted for treatment of chronic back pain complicated by habitual narcotic and diazepam use. He had received succinylcholine during lumbar laminectomy three
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