CAROLINE A. RIELY, M.D.; PATRICIA S. LATHAM, M.D.; ROBERTO ROMERO, M.D.; THOMAS P. DUFFY, M.D.
Grant support: in part by grant AM34989-02, NIDDK, from the Digestive Diseases Research Center.
Presented in part at the 1981 meeting of the American Gastroenterological Association (Gastroenterology. 1981;80:1346 [Abstract]).
▸ Requests for reprints should be addressed to Caroline A. Riely, M.D.; Liver Study Unit, Yale University School of Medicine, 333 Cedar Street; New Haven, CT 06510.
RIELY C., LATHAM P., ROMERO R., DUFFY T.; Acute Fatty Liver of Pregnancy: A Reassessment Based on Observations in Nine Patients. Ann Intern Med. 1987;106:703-706. doi: 10.7326/0003-4819-106-5-703
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Published: Ann Intern Med. 1987;106(5):703-706.
Acute fatty liver of pregnancy was diagnosed in nine patients over a 10-year period. Eight patients had severe hepatic dysfunction typical for this syndrome and one had subclinical disease but typical hepatic histologic findings. All patients survived with little fetal wastage; all had preeclampsia. Histologic findings included cholestasis, hepatocellular necrosis, and inflammation, as well as microvesicular fat. Histologic findings from biopsy specimens of four of seven patients were initially misinterpreted as hepatitis. This disorder may have both a broad clinical and histologic spectrum; it is probably not rare but often misdiagnosed, perhaps as viral hepatitis. The concurrence of this disorder with toxemia of pregnancy suggests that these entities may be pathophysiologically related.
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Gastroenterology/Hepatology, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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