ROBERT E. ENCK, M.D.
To the editor: The observation by Overly and Jakubek (1) regarding the association of multiple squamous cell carcinomas of the skin and a positive serologic test for human immunodeficiency virus (HIV) in a factor-IX-deficient man is interesting but raises an important question regarding the causal relationship. The authors attribute the HIV serologic positivity to treatment with factor IX concentrates over a period of many years.
Before the onset of the acquired immunodeficiency syndrome (AIDS) epidemic, we extensively studied (2, 3) a group of patients with hereditary bleeding disorders (factor VIII deficiency, factor IX deficiency, and von Willebrand disease) at the
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ENCK RE. Squamous Cell Cancers and the Acquired Immunodeficiency Syndrome. Ann Intern Med. 1987;106:773. doi: 10.7326/0003-4819-106-5-773_1
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Published: Ann Intern Med. 1987;106(5):773.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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