MYRON S. COHEN, M.D.; H. E. WASHTON, M.D.
COHEN MS, WASHTON HE. Cefoperazone and Prothrombin Time. Ann Intern Med. 1987;106:778. doi: 10.7326/0003-4819-106-5-778_1
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Published: Ann Intern Med. 1987;106(5):778.
To the editor: In their article on the relationship between beta-lactam antibiotics and coagulopathy, Sattler and colleagues (1) cited our results (2) from a multicenter trial of cefoperazone sodium done in 1982 and 1983. We subsequently examined the effects of cefoperazone sodium on prothrombin time in greater detail (3). The trial included 894 patients. Most patients received 2 g of cefoperazone sodium twice per day. Data on prothrombin time was adequate for analysis in 695 (78%) of patients enrolled in the study. Prothrombin time was abnormal in 12 patients (1.7%) before therapy; was changed by less than 2 seconds during
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