WERNER O. RICHTER, M.D.; GERD BREHM, M.D.; PETER SCHWANDT, M.D.
RICHTER WO, BREHM G, SCHWANDT P. Type V Hyperlipoproteinemia and Plasmapheresis. Ann Intern Med. 1987;106:779. doi: 10.7326/0003-4819-106-5-779_1
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Published: Ann Intern Med. 1987;106(5):779.
To the editor: Patients with excessive type V hyperlipoproteinemia develop several forms of abdominal pain that can be caused by three mechanisms: painful and tender spleen and liver, intestinal dysfunction, and pancreatitis (1-3). Pancreatitis is the most serious complication and can result in death (4). High serum levels of chylomicrons (triglycerides in concentrations greater than 1000 mg/dL) cause these complications through an increase in plasma viscosity (5); therefore, severe pancreatitis, intractable abdominal pain, and other complications such as seizures or gastrointestinal hemorrhage need to be treated by the induction of a rapid decrease in the level of chylomicrons in blood.
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