MATJAž ZWITTER, M.D., M.SC.; JOžE DRINOVEC, Ph.D.; MIRKO DUBRAVČIĆ, M.D.; ALENKA VODNIK, M.D.; JELKA PETRIČ-GRABNAR, M.D.; MAJDA DOLNIČAR, M.D.; MIODRAG KONSTANTINOVIĆ, Ph.D.; žARKA žEMVA, M.SC.
ZWITTER M, DRINOVEC J, DUBRAVČIĆ M, VODNIK A, PETRIČ-GRABNAR J, DOLNIČAR M, et al. Cyclosporine May Alleviate B Symptoms and Induce a Remission of Heavily Pretreated Hodgkin Disease: A Preliminary Report. Ann Intern Med. 1987;106:843-844. doi: 10.7326/0003-4819-106-6-843
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Published: Ann Intern Med. 1987;106(6):843-844.
The outlook for patients with Hodgkin disease in relapse after receiving several combinations of cytotoxic drugs is still unfavorable. Our preliminary experience with cyclosporine indicates that the introduction of a new drug and a new therapeutic approach deserves further attention in Hodgkin disease, and possibly in other lymphoproliferative disorders.
Ten patients with Hodgkin disease who had a biopsy-proven relapse after first- and second-line chemotherapy participated in the study (Table 1). All patients had measurable extranodal disease with B symptoms, normal renal function, and gave informed consent for a new treatment.
Cyclosporine was taken orally twice daily, diluted in milk or
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