HENRY W. B. SMITH, M.D.; HENRY A. LIBERMAN, M.D.; STEVEN L. BRODY, M.D.; LOUIS L. BATTEY, M.D.; BRYAN C. DONOHUE, M.D.; DOUGLAS C. MORRIS, M.D.
SMITH HWB, LIBERMAN HA, BRODY SL, BATTEY LL, DONOHUE BC, MORRIS DC. Acute Myocardial Infarction Temporally Related to Cocaine Use: Clinical, Angiographic, and Pathophysiologic Observations. Ann Intern Med. 1987;107:13-18. doi: 10.7326/0003-4819-107-1-13
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Published: Ann Intern Med. 1987;107(1):13-18.
Ischemic chest pain syndromes and myocardial infarction occurred within minutes to hours of cocaine use in nine persons ages 23 to 39 years. Five developed symptoms after taking cocaine intranasally; three, after intravenous use; and one, after smoking cocaine. Four were habitual users and five were recreational users; eight also smoked cigarettes heavily. Ischemic syndromes recurred in five who continued to use cocaine. Coronary arteriography showed an abnormal infarct-related vessel (more than 50% stenosis, total occlusion, or intraluminal thrombus) in seven patients. The noninfarct-related vessels were normal in eight patients. The left anterior descending coronary artery and the anteroapical left-ventricular wall were involved in all patients. After three patients had successful thrombolysis of the obstructed infarct-related vessel, angiography showed a normal underlying vessel.
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Cardiology, Emergency Medicine, Tobacco, Alcohol, and Other Substance Abuse, Acute Coronary Syndromes, Coronary Heart Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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