G. MARIANI, M.D.; A. GHIRARDINI, M.D.; F. MANDELLI, M.D.; P. VERANI, M.D.; S. BUTTÓ, Ph.D.; G.B. ROSSI, M.D.; P. M. MANNUCCI, M.D.
MARIANI G, GHIRARDINI A, MANDELLI F, VERANI P, BUTTÓ S, ROSSI G, et al. Heated Clotting Factors and Seroconversion for Human Immunodeficiency Virus in Three Hemophilic Patients. Ann Intern Med. 1987;107:113. doi: 10.7326/0003-4819-107-1-113
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Published: Ann Intern Med. 1987;107(1):113.
To the editor: Clotting factor concentrates have been heated since 1984 to inactivate human immunodeficiency virus (HIV). Hemophilic patients seronegative for HIV treated exclusively with heated concentrates at first showed no seroconversion (1-3). Later, two hemophiliacs seroconverted after having been treated with the same factor VIII concentrate that had been heated in the lyophilized state (freeze-dried) at 60 °C for 30 hours (4, 5). This relatively low heating temperature and short time period might be insufficient to inactivate HIV. During our follow-up of 63 hemophiliacs who were seronegative before the exclusive usage of heated concentrates was initiated, three became persistently
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