G. MARIANI, M.D.; A. GHIRARDINI, M.D.; F. MANDELLI, M.D.; P. VERANI, M.D.; S. BUTTÓ, Ph.D.; G.B. ROSSI, M.D.; P. M. MANNUCCI, M.D.
MARIANI G., GHIRARDINI A., MANDELLI F., VERANI P., BUTTÓ S., ROSSI G., MANNUCCI P.; Heated Clotting Factors and Seroconversion for Human Immunodeficiency Virus in Three Hemophilic Patients. Ann Intern Med. 1987;107:113. doi: 10.7326/0003-4819-107-1-113
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Published: Ann Intern Med. 1987;107(1):113.
To the editor: Clotting factor concentrates have been heated since 1984 to inactivate human immunodeficiency virus (HIV). Hemophilic patients seronegative for HIV treated exclusively with heated concentrates at first showed no seroconversion (1-3). Later, two hemophiliacs seroconverted after having been treated with the same factor VIII concentrate that had been heated in the lyophilized state (freeze-dried) at 60 °C for 30 hours (4, 5). This relatively low heating temperature and short time period might be insufficient to inactivate HIV. During our follow-up of 63 hemophiliacs who were seronegative before the exclusive usage of heated concentrates was initiated, three became persistently
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